ABSTRACT
Our research aimed at the chemical and biological investigations of selected endophytes associated with Garcinia preussii. The chemical investigation of the crude extract from the solid state fermentation of Aspergillus japonicus, an endophytic fungus harboring leaf of Garcinia preussii, by means of Liquid chromatography-Mass spectrometry (LC-MS) led to the isolation of two major compounds. Their structures were elucidated on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. These isolated compounds were found to be variecolin (1) and neovasifuranone B (2) from the cyclohexane fraction. The antimicrobial studies showed that the isolated compounds exhibits antibacterial activity with inhibition zone diameters varying from 09.0±0.00 to 11.0±0.00 mm. These preliminary results showed promising activity of these compounds thus supporting the immensity of the potential of antibacterial drug discovery from miroorganisms.